At present, TG is permanently hosed if you lose the mysql connection. This can happen if the connection times out, or the server is restarted. This is not going to fly in a production environment, or in one where your hosting provider does dumb things to the database settings.
On Mark Ramm's request, I am filing this ticket so that once MySQLdb exposes an auto-reconnect interface, SQLObject/Gears can make use of it.
I have submitted a patch to the MySQLdb sourceforge that exposes the interface. Hopefully they will add it soon. Link:http://sourceforge.net/tracker/index.php?func=detail&aid;=1483074&group;_id=22307&atid;=374934
Here's a thread on this topic, which includes a quicker hardcoded workaround (also in the MySQLdb code -- I couldn't find any other way to do it):
http://groups.google.com/group/turbogears/browse_frm/thread/4f0ae451e72b4717/7cfd7592010b4959?lnk=arm#7cfd7592010b4959